Peptide Coupling Reagent
CAS: 693-13-0
N,N-Diisopropylcarbodiimide
N,N'-Diisopropylcarbodiimide (DIC, DIPCDI, DIPC) is a high-purity carbodiimide zero-length coupling reagent used in solid-phase peptide synthesis (SPPS), amide bond formation, and organic synthesis. Designed for carboxylic acid activation and esterification, DIC forms an organic-soluble urea byproduct (N,N-diisopropylurea) for easy wash-based purification. Available in research, commercial, and bulk quantities with fast dispatch from Hyderabad, India.
| Pack Size | Stock | Price (₹) | Quantity | Delivery Time | Action |
|---|---|---|---|---|---|
| 25 g | 20 |
₹990
₹990
|
1
|
5–7 Business days |
|
| 100 g | 20 |
₹2,490
₹2,490
|
1
|
5–7 Business days |
|
| 250 g | 10 |
₹5,290
₹5,290
|
1
|
5–7 Business days |
|
| 500 g | 5 |
₹9,490
₹9,490
|
1
|
5–7 Business days |
|
| 1 kg | 5 |
₹15,990
₹15,990
|
1
|
5–7 Business days |
|
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| Category | Peptide Coupling Reagent |
| Chemical Name | 1,3-Diisopropylcarbodiimide |
| CAS No. | 693-13-0 |
| Synonyms | DIC, DIPCI, 1,3-Diisopropylcarbodiimide, N,N-Methanetetraylbis(2-propanamine), Diisopropylmethanediimine |
| Chemical Formula | C7H14N2 |
| Molecular Weight | 126.20 g/mol |
| Applications | Solid-Phase and Solution-Phase Peptide Synthesis (SPPS).Carboxylic acid activation for esterification and amidation.Cross-linking agent in bioconjugation and polymer chemistry.Synthesis of anhydrides, aldehydes, ketones, and heterocycles. |
| Test | Specification |
|---|---|
| Purity | >99% (HPLC) |
| Appearance | White crystalline powder |
| Storage | Room Temperature |
Usage
N,N'-Diisopropylcarbodiimide (DIC) is an essential carbodiimide coupling reagent utilized in solid-phase peptide synthesis (SPPS) and solution-phase peptide synthesis. Ideal for carboxylic acid activation, amidation, and esterification, DIC operates effectively at temperatures from 0°C to ambient in organic solvents such as DCM, DMF, THF, or Acetonitrile. Unlike DCC, DIC produces an organic-soluble byproduct (N,N'-diisopropylurea), facilitating effortless wash-based purification and high-yield target isolation in complex peptide and pharmaceutical synthesis.
Safety
DANGER: Flammable liquid and vapor (H226). Fatal if inhaled (H330). Causes severe eye damage (H318) and skin irritation (H315). May cause allergic skin reaction or asthma symptoms (H317, H334).
UN Number: UN2929 | Hazard Class: 6.1 (3) Toxic & Flammable | Packing Group: I
Handling: Handle exclusively in a certified chemical fume hood using appropriate personal protective equipment (PPE), including chemical-resistant gloves, eye protection, and full skin coverage. Avoid vapor inhalation and contact.
UN Number: UN2929 | Hazard Class: 6.1 (3) Toxic & Flammable | Packing Group: I
Handling: Handle exclusively in a certified chemical fume hood using appropriate personal protective equipment (PPE), including chemical-resistant gloves, eye protection, and full skin coverage. Avoid vapor inhalation and contact.
Other Information
Store at 2°C to 8°C under an inert gas atmosphere (Nitrogen or Argon) in a tightly sealed container. Keep in a cool, dry, well-ventilated area away from heat, sparks, open flames, and direct sunlight. DIC reacts slowly with atmospheric moisture; store strictly protected from water and humidity.
Commercial & Bulk Procurement Information
Hestur Pharma is a trusted manufacturer and supplier of N,N'-Diisopropylcarbodiimide (DIC, CAS 693-13-0) in Hyderabad, India. We offer high-purity coupling reagents for peptide synthesis (SPPS), amide bond formation, and custom organic synthesis, available from lab scale to commercial bulk B2B quantities.
Commercial & Bulk Procurement Information
Hestur Pharma is a trusted manufacturer and supplier of N,N'-Diisopropylcarbodiimide (DIC, CAS 693-13-0) in Hyderabad, India. We offer high-purity coupling reagents for peptide synthesis (SPPS), amide bond formation, and custom organic synthesis, available from lab scale to commercial bulk B2B quantities.
